Sermorelin (INN) (trade name is Geref), also known as GHRH (1-29), is a growth hormone-releasing hormone (GHRH) analogue used as a diagnostic agent. It is a 29-amino acid polypeptide representing the 1-29 fragment from endogenous human GHRH, and is thought to be the shortest fully functional fragment of GHRH. It is used as a diagnostic agent to assess growth hormone (GH) secretion.
Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth -releasing hormone (GHRH or GRF) consisting of 44 amino acid residues.
It stimulates the pituitary gland to naturally produce increased amounts of human growth . Sermorelin Acetate is a truncated analog of a growth releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production of human growth . The increased volume of human growth () produced by the pituitary gland causes an increase in the production of Insulin-Like Growth -1 (IGF-1) by the liver and results in the benefits of treatment provided to the adult patient.
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