Application
Andarine is a SARM with utmost androgenic effects as it around 33% of the strength of testosterone when attaching to AR. Andarine also increases the amount of muscle mass produced by desensitizing the AR to the individual’s natural testosterone to influence a stronger effect.
Andarine is by far the most versatile SARM ever created. Not only is it the first SARM approved for a stage 2 research study, it has become the most analyzed and investigated SARM so far. After the discovery of its anabolic potential, the primary purpose of Andarine aimed to develop an alternative treatment to age-related muscle wasting, osteoporosis, and similar symptoms of hypogonadism, or end-stage renal disease.
Aside from preserving lean body mass, Andarine can also help improve it. From a stage 1 study, Andarine has provided evidence of a 3.3 lbs increase in less than 90 days with no increases exercise or change in daily diet. An unintended side effect (or benefit if you will) is the decrease in body fat. Decreases in body fat are dependent on the person’s genetics, but it will definitely have strong effects on the body’s ability to oxidize fatty tissue. Andarine was found to not only have a great affinity (potency in binding to androgen receptors), while also presenting greater anabolic effects than some traditional steroids.
Aside from its muscle building advantages, Andarine won’t cause liver damage, can prevent gynecomastia (enlarged breasts in men) and can help boost your overall health.
Description
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
Andarine is an orally active partial agonist for androgen receptors.It is less potent in both anabolic and androgenic effects than other SARMs.In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.[3] This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.
Effects
The effects of Andarine (S4) can range from bulking to cutting and total body transformation; however, bulking (muscle/mass gains) will be the weakest of the three areas. S4 is not known for packing on a lot of lean muscle tissue, but lean gains can and should be made providing enough calories are present along with muscular stimulation (exercise). For the off-season athlete looking to really pack on size, this is not a product they’ll want to base their plan around although it could be a solid addition to a plan, simply not a standalone item. Andarine is well known for aiding in strength increases. Increasing strength can be a benefit when trying to grow as it allows the individual to lift heavier weights. However, strength and size do not always go hand-in-hand and cannot be used as a gauge when trying to grow. It is very possible to gain little to no weight and still increase strength despite no increases in size.
Cutting will be where Andarine (S4) really stands out and for several reasons. The primary objective of any cutting plan is to lose body fat. In order to lose body fat one must burn more calories than he consumes, which will put lean muscle tissue at risk. S4 supplementation can provide the means to protect muscle tissue during a calorie deficit. The more tissue that’s preserved, the stronger the metabolism will continue to burn. If tissue is lost, the metabolism can slow making fat loss more difficult. Some data has also shown S4 to directly increase lipolysis (fat loss) although it is unclear how significant this affect is. Equally beneficial to the cutting plan, Andarine has been shown to increase hardness and definition significantly in a lean physique. Hardening and strength effects of this SARM have often been compared to the anabolic steroid Winstrol. As an added bonus, with the strength increasing traits of S4, while strength may not increase when cutting, if using this SARM you may very well find you maintain a lot more of your strength that would have otherwise diminished.
For the every day fitness enthusiast, this may be one of the best SARM’s on the market. It’s not possible to gain a massive amount of muscle and shred up with any product. If you want to go to the extreme in either direction, you have to pick one direction at a time. But if you’re looking for more of a transformation, not necessarily large increases in size or ripped to the bone but more of a beach body look with increases in athletic performance, this is one of the better SARM’s available. Due to the side effect friendly nature, it’s also one of the more appealing.
Right Dosing
S-4 should be taken at 50mg-75mg, 5 days out of the week, for 12-16 weeks. As mentioned before, S-4 does not need to be taken on 3 separate occasions throughout the day; but for individuals that prefer this method, a 25mg dose (roughly half a milliliter) is recommended once with each of your three main meals.
Once again, as mentioned above, S-4 does have point of diminishing returns. This means usage of S-4 passed 75mg or usage of S-4 for more than 16 weeks will not result in any added muscle mass. There will not be an increase in side effects either, but you will be running the risk of AR desensitization and inevitably wasting your product. Dosing with S-4 for less than 6-8 weeks is not recommended and will not allow the researcher to witness the full benefits of the product.
Recommended dose for cutting is 50 mg for 6-8 weeks. You should use it every day then take 2 days off for the duration. Taking S4 daily for the length of the cycle can lead to changes in eyesight.
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