PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte-stimulating hormone. MSH activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts a potent influence over lipid metabolism, appetite, and sexual libido. Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning. Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.
As a lifestyle peptide, the 10mg product is a lot to consume and may offer up to 20 doses when dosing lightly. The PT-141 peptide reconstituted with bacteriostatic water remains potent in the fridge for months.
PT-141 / Bremelanotide is a synthetic heptapeptide analog of the naturally occurring α-MSH that is currently being studied for its numerous theoretical therapeutic applications. Alpha-MSH has a potent influence over lipid metabolism, appetite, and sexual libido.
PT-141/ Bremelanotide is a metabolite of its predecessor MT-2, has the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH and a molecular weight of 1025.2 Dalton.
In initial testing, MT-2 did induce melanogenesis, but caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects.





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