Abstract

LGD-4033 is rapidly increasing in popularity, as it has shown to be the strongest and most anabolic-like SARM in existence up to this point. SARMS are quite different from steroids in terms of their makeup, lack of side effects and recovery time. SARMS can be run much longer than oral steroids. They are non-methylated and don’t pressure the liver. Although the results are not as drastic as some steroids, they are much cleaner, more keepable and have several properties that are extremely desirable that steroids may not be able to provide.

LGD-4033 is a selective androgen receptor modulator (SARMS), and a novel non-steroidal oral SARM that binds to AR with high affinity (Ki of ~1 nM) and selectivity. It’s in a class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. LGD-4033 is expected to produce the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an oral route of administration.

User Feedback

LGD4033, LGD – Unparalleled for very lean bulking. 3 weeks of just 1mg per day can add nearly 4 pound of lean mass without exercise, in males. Usual dose is 2.5-10mg, beyond that, you’re asking for hypoglycemia and other issues.

There’s very little point to anything beyond that, for most people the diminishing returns begin at 5mg. It loads your muscles full of water and glycogen, rapidly increasing the amount of exercise volume you can do at any given percentage of your max. My best example is that when my squat max was 355, my 20rm was 245 easily after 20 rep set of 225. Pumps are insane, and most users have a significant appetite increase and nutrient demand.

During my long term use of this, I retained much of the nutrient partitioning effects for some time after the cycle. I think there may be some gene expression change toward building muscle that LGD affects. I noticed similar difficulty losing fat however, mild caloric restriction absolutely destroyed my energy.