Letrozole, sold under the brand name Femara, is a medication primarily used in the treatment of breast cancer in postmenopausal women. It belongs to a class of drugs called aromatase inhibitors, which work by reducing the production of estrogen in the body. Letrozole is considered a highly effective and commonly prescribed treatment option for certain types of breast cancer.
Here are some important details about Letrozole:
Mechanism of Action:
Letrozole inhibits the enzyme aromatase, which is responsible for the conversion of androgens (male hormones) into estrogens (female hormones). By blocking this enzyme, Letrozole reduces estrogen levels, which helps slow down or stop the growth of hormone receptor-positive breast tumors.
Indications:
Letrozole is primarily used in the treatment of hormone receptor-positive breast cancer, which means the cancer cells have receptors that bind to estrogen. It is specifically prescribed for postmenopausal women, as estrogen production in premenopausal women primarily occurs in the ovaries, whereas in postmenopausal women, it mainly occurs in peripheral tissues through the conversion of androgens. Letrozole is often given after other treatments, such as surgery or tamoxifen, have been attempted.
Dosage:
The usual recommended dose of Letrozole for breast cancer treatment is 2.5 mg once daily. It is taken orally, with or without food. The duration of treatment may vary depending on the individual and the specific requirements of their cancer treatment.
Side Effects:
Like any medication, Letrozole can cause side effects. Common side effects may include hot flashes, joint pain or stiffness, fatigue, headache, increased sweating, nausea, and dizziness. Some women may also experience bone thinning or osteoporosis as a result of reduced estrogen levels. It is important to discuss any side effects with your healthcare provider, as they may be able to offer suggestions to manage or alleviate them.
Precautions and Contraindications:
Letrozole is generally not prescribed for premenopausal women, as it may interfere with normal hormonal function. It is important to inform your doctor about any other medications you are taking, as Letrozole may interact with certain drugs. Additionally, Letrozole is contraindicated in women who are pregnant or breastfeeding.
Monitoring:
Regular medical check-ups and monitoring are essential during Letrozole treatment to evaluate its effectiveness and assess for any potential side effects or complications. This may include blood tests, bone density assessments, and imaging studies.
It is crucial to note that the information provided here is a general overview and should not replace the advice and guidance of a qualified healthcare professional. If you have specific questions or concerns about Letrozole or any other medication, it is best to consult your doctor or oncologist for personalized information.




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