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Growth hormone releasing peptide-2 (GHRP-2) is in the category of drugs known as GH secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin.Their primary function is to stimulate the pituitary gland to produce more growth hormone. GHRPs have a 2-fold mechanism of action, in that they cause an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of somatostatin.GHRP-2 is a 2nd generation GHRP and finds its primary use in the area of GH release. It is superior to GHRP-6 in this regard and is currently the preferred peptide for attaining maximum elevations in GH over the long-term. Recent research also reveals that GHRP-2 can be dosed much higher than initially thought, while avoiding the desensitization that is inherent in some of our other GHRP’s. This provides the user with the opportunity to experience greater elevations in total GH, depending on the dosage administered.

Lastly, while GHRP-2 can potentially lead to some degree appetite stimulation, not all users experience this effect and when they do, it is typically much less profound in comparison to GHRP-6.

Difference between GHRP-2 and GHRP-6

GHRP-6 causes a significant increase in hunger for many, therefore making it good for people looking to “bulk” but no so good for those trying to lose fat. GHRP-2 is often preferred for people dieting as it does not stimulate hunger, however it does raise cortisol (a stress hormone),prolactin (a hormone which can diminish sex drive) and aldosterone (a hormone which promotes water retention) more than GHRP-6 and Ipamorelin. Ipamorelin is similar to GHRP-6 in that it causes an increase in hunger (but it’s not as dramatic as GHRP-6). However, since it does not raise cortisol, prolactin or aldosterone at recommended dosages it is a preferred choice for those who are sensitive to these hormones.