AICAR 10mg Detailed Description
Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.
AICAR 10mg Applications
The Acadesine, with the CAS registry number 2627-69-2, has the systematic name 5-amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide. Its molecular formula is C9H14N4O5 and its product categories are Bases & Related Reagents; Carbohydrates & Derivatives; Nucleotides; Protein Kinase storage Temp. However, keep it at -20 °C.
Other characteristics of the Acadesine can be summarised as followings: (1)ACD/LogP: -3.87; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -3.87; (4)ACD/LogD (pH 7.4): -3.87; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 9; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 78.29 Å2; (13)Index of Refraction: 1.821; (14)Molar Refractivity: 54.55 cm3; (15)Molar Volume: 125.2 cm3; (16)Polarizability: 21.62×10-24cm3; (17)Surface Tension: 106.5 dyne/cm; (18)Density: 2.06 g/cm3; (19)Flash Point: 393.1 °C; (20)Enthalpy of Vaporization: 111.33 kJ/mol; (21)Boiling Point: 726.3 °C at 760 mmHg; (22)Vapour Pressure: 3.83E-22 mmHg at 25°C.
Uses of this chemical: The Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. It is also an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
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